Li-Ping Zhu1,
Cheng-Jun Yan2,
Qing-Jian Wu2,
Cun-Xue Zhang1,
Xiu-Tai Yuan1,
Ti-Kun Fang2 
For correspondence:- Ti-Kun Fang Email: fangtikun@hotmail.com Tel:+865372253684
Received: 9 December 2016 Accepted: 7 June 2017 Published: 31 July 2017
Citation: Zhu L, Yan C, Wu Q, Zhang C, Yuan X, Fang T. Assessment of changes in lipid profile and related enzymes in children with asthma. Trop J Pharm Res 2017; 16(7):1711-1716 doi: 10.4314/tjpr.v16i7.32
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the influence of the lipid profile and related parameters on the development of asthma in children aged 10 to 15 years.
Methods: Peripheral blood samples were collected from a group diagnosed with asthma as well as from a healthy control group. The lipid profile parameters measured were total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), high-density lipoprotein (HDL), serum total antioxidant capacity (TAC), reduced glutathione (GSH), and malondialdehyde (MDA), and the activities of lecithin–cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP).
Results: TC, TG, LDL, and VLDL levels were significantly (p ≤ 0.05) higher in the asthma group compared with the controls, while HDL level was lower. Total TAC and GSH were lower in the asthma group, while MDA level, and LCAT and CETP activities were higher.
Conclusion: There is a link between an elevated lipid profile and increased antioxidant capacity in asthmatic children.
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